Many businesses offer more literature than any other type of product, and for these businesses holding large amounts of literature it is costly to store this inventory. For many businesses, it is much less expensive to use a literature fulfilment company to handle this end of business. Not only do literature fulfilment companies offer your business the chance to save on inventory storage, but the headache of returns and shipping. Most literature fulfilment companies will find the least expensive delivery carriers for your products to be shipped with, but they also take care of all returns and exchanges.

These two actions alone take up an average of 23% of a business’ time when it comes to peak seasons. This is time that could be better used dealing with the sales and marketing end of your business.

Instead of holding your own inventory and dealing with the overhead for this requirement, simply using a literature fulfilment company will help to alleviate the troubles associated with inventory and your company no longer has to deal with any of these problems. The product your customers purchase can be handled through a fulfilment company’s automatic online service or you can place the order on their behalf. This allows your customers faster delivery times because most literature fulfilment businesses will offer 24 hour turnaround service and shipping. Your business not only gets less work due to using this business, but also gains a reputation for fast delivery and great products.

Many fulfilment companies will offer monthly or annual packages for your literature fulfilment needs. When deciding on your literature fulfilment company, ask about a dedicated account manager for your business and what systems will be used for your fulfilment.

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The Prime Minister, Gordon Brown, announced in his key speech at this year’s Labour Party conference that he plans to bring in speedier testing for cancer in patients showing symptoms of the disease.  This will mean earlier diagnosis and earlier treatment, and could potentially save thousands of lives.  This promise is building upon what the NHS has already achieved since it received extra funding and brought down the age for breast cancer screening, which has already made a difference to many women’s lives. 

In his speech, Gordon Brown pledged to “finance a new right for cancer patients to have diagnostic tests carried out, completed and with results – often same day results - within one week of seeing your GP. That is our early diagnosis guarantee, building on our current guarantee of only two weeks wait to see a specialist.” The Labour Party promises to meet this target by 2014. 

Initially the proposal will be implemented for lung, colorectal and ovarian cancers, with other cancers being brought into the service within 5 years. Funding which has previously been used for making improvements to hospital buildings will now be used to provide more diagnostics equipment within GP surgeries and community hospitals, including CT scanners.

So how will this be implemented?  Leading cancer expert, Professor Mike Richards, will be leading the new initiative and has stated that it will involve new roles for nurses who will play an important role in carrying out many of the tests, including endoscopies and ultrasounds.  The investment in the initiative will create further training opportunities for nurses and could create more nurse jobs.  Nursing jobs could also involve raising more awareness of cancerous symptoms, such as unexpected weight loss, changes in bowel habits, persistent coughing or noticeable changes to a mole or wart. This will build upon the nurse’s role in cancer care as rehabilitative carer, where they address rehabilitation issues for patients in teaching, counseling and guidance.

However, there is a fear that the new responsibilities could add pressure to nurses who are already buckling under the strain of a large workload.  It could prove challenging to implement the gold standard of clinical examination, ultra sound and pathology in the shorter time frame, bringing into question the quality of the diagnosis as well as the speed.

The new early diagnosis will benefit those patients who show some cancerous symptoms but do not fulfill all the conditions for immediate referral to a specialist.  For example, if a young woman found a small lump in her breast, she is below the common age for breast cancer, so may not be referred to a specialist so quickly.  The new scheme will be particularly helpful in detecting ovarian cancer, which can be hard to spot as it presents indistinct symptoms. The chief executive of Ovarian Cancer Action, Peter Reynolds, has stated that most women with ovarian cancer were currently diagnosed with the disease at a later stage, making treatment harder and bringing the success rate down.

Although there are no accurate data for concordance rates of leukaemia in infant twins, it seems to be very high, and perhaps approaching one hundred percents. If this is correct, it suggests that MLL gene fusion in utero has a dramatic impact, ensuring subsequent leukaemia. But for children aged between two and six years who have acute lymphoblastic leukaemia, the concordance rate is considerably lower at around five percents.

This still represents a one hundred fold extra risk of leukaemia for the twin of a patient with acute lymphoblastic leukaemia but also indicates the need for some additional postnatal events for which there is a one in twenty chance, or ninety five percent discordance. This actually suggests, at a minimum, a two hit model for the natural course of childhood leukaemia.

If this model of leukaemia development is correct, then for every child with acute lymphoblastic leukaemia diagnosed, there should be at least twenty healthy children who actually have had a chromosome translocation, a functional leukaemia fusion gene, and a covert pre leukemic clone generated in utero.

This possibility has been investigated by screening unselected samples of newborn cord blood for fusion genes. Cord blood is actually the best place to find stem cells especially if you want to do umbilical cord blood collection and then go to a cord blood bank or stem cell bank to store it just in case.

The real bottleneck in development of acute lymphoblastic leukaemia therefore seems to be a stringent requirement for a second hit after birth, which is exposure and additional chromosomal or molecular abnormality.

A key issue to resolve is what exposures or events might precipitate the chromosome breaks whose improper repair initiates or promotes childhood leukaemia. Given the biological diversity of leukaemia, it is highly unlikely that there is a single cause. Even for a defined biological subtype of the disease, there probably is not one cause as such but a causal mechanism. As with other cancers, this is likely to involve an interaction of exposure with inherent genetic susceptibility, and chance.

Epidemiological evidence suggests that ionising radiation, certain chemicals, viruses and bacteria may actually play a part in the development of some subtypes of leukaemia and lymphoma in adults and children. Whether any of these exposures have a major role in childhood leukaemia is uncertain, but large scale case control molecular epidemiological studies in Great Britain and the United States if America may provide answers. Doing stem cell storage or cord blood storage in a cord blood bank or a stem cell bank could be a good solution as breakthrough seems to happen more and more often.

"Those who fail to take the time to be healthy will ultimately have to take the  time to be sick." ~  Dr. James Chappell

So you want to enjoy a long, healthy, happy life or should I say, you want to be the “exception to the rule.”

You should know from the start that the “odds” are stacked against you, but by accepting and tackling the challenge you will find it very worthwhile and rewarding, not to mention adding many years of happiness onto your lifespan.